Study On The Formation Of Cyclodextrin Inclusion Complex
The intrinsic factors of cyclodextrin inclusion formation depend on the basic properties of cyclodextrin and its object:
Hydrophobic interaction between the 1 main objects
Due to the hydrophobic cavity of cyclodextrin and guest molecules of non polarity is higher, more easily wrapped. When the hydrophobic guest molecules of fat into the cyclodextrin cavity after, the hydrophobic groups and the cyclodextrin cavity has the maximum contact, and the hydrophilic group away from the cavity.
2 subject object matching effect
The size of the ring is different, they can choose to accommodate the size of the object and the size of the cavity, so the formation of inclusion complex is stable.
3 hydrogen bonds with the release of high-energy water
Some guest molecules and cyclodextrin hydroxyl groups can form hydrogen bonds, increases the packet, the stability of the complexes. The hydrophobic part of the object into the cyclodextrin cavity facilitates formation of inclusion complexes of cyclodextrin is replaced by cyclodextrin high-energy water, because the polarity of water molecules in non polar cavity less stable, easy to be extremely low molecular replacement.
Shandong Binzhou Zhiyuan Biological Technology Co., Ltd. is a professional cyclization of cyclodextrin and its derivatives are used, development, science and technology innovation company. By packages of cyclodextrin complexes formation conditions of research, the company has developed a variety of cyclodextrin inclusion complexes, the formation of a series of characteristics of small products.
Alpha Cyclodextrin sulfate & Hydrocortisone phosphate
Alpha-Cyclodextrin (synonyms: cyclohexaamylose, cyclomaltohexaose, alpha-Schar-dinger dextrin) is a non-reducing cyclic saccharide comprised of six glucose units linked by alpha-1, 4 bonds.
It is produced by the action of cyclodextrin glucosyltransferase (CGTase, EC 2.4.1.19) on hydrolysed starch syrups at neutral pH (6.0–7.0) and moderate temperature (35–40°C).
The annular (or doughnut-shaped) structure of alpha-cyclodextrin provides a hydrophobic cavity that allows formation of inclusion complexes with a variety of non-polar organic molecules of appropriate size.
The hydrophilic nature of the outer surface of the cyclic structure makes alpha-cyclodextrin water-soluble.
Other name: Cyclohexapentylose
CAS Registry Number: 10016-20-3
MF: C36H60O30
MW: 972.84
EINECS NO.: 233-007-4
Appearance: white crystalline or powder
Assay:99%min
[Structure]
[ Properties Computed from Structure]
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Gamma-cyclodextrin is a ring-shaped molecule made up of eight glucose units linked by alpha-1,4-bonds. The solubility degree of gamma-cyclodextrin in water is 23.2 g/100ml @ 25°C, which is higher than alpha-cyclodextrin and beta-cyclodextrin, and it is used to allow formation of inclusion complexes with bigger molecules.
CAS No.: 17465-86-0
Molecular Formula: C48H80O40
Molecular Weight: 1297.12
Application:
Gamma-cyclodextrin can be used as a carrier for flavours, sweeteners, and colours. In chemistry it is a valuable chemical reagent. When gamma-cyclodextrin exists, fluorescence intensity of fluorescence pigment will become much bigger, so it is used as the analysis of protein and amino acid. Gamma-cyclodextrin is also used to separate long-chain organic compound, racemic modification and so on. Besides, the adsorbent made by gamma-cyclodextrin is used chromatographic analysis. It also can be used as complexing agent and cultivation agent in study of enzymatic activity.
γ-cyclodextrin, Gamma Cyclodextrin Pharmaceutical Grade
Zhiyuan Biotchnology , http://www.zycydextrin.com